Protocol Concept

The comprehensive proposal application will ask for the following information (if applicable):

  • NIH Biosketch of proposing investigator
  • Study rationale
  • Hypothesis
  • Primary objective(s) and endpoint(s)
  • Study centers (proposed)
  • Study population
  • Study design
  • Intervention/treatment
  • Sample size estimate
  • Timeline and length of participant follow-up
  • New and/or unique assay
  • External support/collaboration/funding
  • Publication references
  • Estimated costs in $ (direct)

Proposals will be carefully reviewed by the applicable ARLG committee. If you have not received a response from an ARLG representative within six weeks, please contact us at


“When I started out in my career researching new diagnostic approaches for host-gene expression, I often encountered skepticism and received many negative responses from conventional funding sources. However, ARLG recognizes that we cannot continue with the same approach and expect a different solution.

Ephraim Tsalik, MD, PhD
Duke University Medical Center

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