The ARLG Laboratory Center supports the ARLG research agenda by leading the assessment, development, and implementation of laboratory-based ARLG studies, and addressing the laboratory needs of non-laboratory-based ARLG studies, by providing expertise, coordinating laboratory services, and supervision of ARLG-affiliated laboratories. The laboratory center is comprised of a director, associate director, and a consortium team, alongside an operational support team.
The ARLG Virtual Biorepository is a resource is comprised of clinically well‐characterized Gram‐positive and Gram‐negative bacterial isolates from manuscripts published by and maintained in the laboratories of contributing investigators or in the ARLG Physical Biorepository.
The ARLG Physical Biorepository is a centralized location, managed by the ARLG Laboratory Center staff, where strains from ARLG-funded studies are stored.
The ARLG Virtual Biorepository Catalogue is a web based system that provides investigators with a searchable view of available strains. For help with using the catalogue website, please refer to this Quick Reference Guide.
Note: The search feature is limited to finding isolates based upon the types of tests done on them. For sorting through strain results for a particular result characteristics, use the Advanced Search to download up to 1000 strains to Excel, then use the filter options to find strains of interest (e.g., strains that are resistant to colistin).
Yes. The list is generated by performing a quick (or advanced) search within the ARLG Virtual Biorepository Catalogue by clicking on the search button. The resulting strain list can then be printed from the browser window.
Available strain information includes strain demographics plus genotypic and phenotypic data as reported in the cited publication(s) for a strain. Links to the PubMed references are provided on the catalogue page.
Depending on either the publication, certain strains may be co-listed as part of a collection (e.g., ARLG-C56). Collections are designated with ARLG-C# within the ARLG Virtual Biorepository Catalogue, and are typically found as the last records following a strain search. ARLG Laboratory Center staff can provide assistance with the selection of individual strains from a collection.
The ARLG strain panels are comprised of well-characterized strains to be used as reference standards for research, development of diagnostic platforms, and/or drug testing.
These strains are housed in the contributing investigators’ laboratories as part of their collection or to the ARLG Physical Biorepository.
No. Verification of the published data associated to the Virtual Biorepository strains is left to the discretion of the providing laboratories. The ARLG Virtual Biorepository Catalogue reports only strain data from published studies. Due to the “virtual” status of the strains, the ARLG cannot warrant the accuracy of the published information.
Strain Request Procedures
Yes, the catalogue is open to the public for browsing. Requests should be emailed to email@example.com. You will receive a link to a short questionnaire. The request for strains will be honored only after approval by the ARLG Laboratory Center firector and/or the ARLG Executive Committee and verification that the receiving laboratory and investigator have Biosafety Level 2 (BSL2) capability to receive strains.
Yes. They should follow the procedures as described in the previous questions and using this Reference Guide.
Yes, please e‐mail your request to firstname.lastname@example.org. The Laboratory Center staff will work with you to select strain(s) best suitable for your study.
A total of 80 strains may be requested per year. A larger number of isolates may be available to ARLG collaborators.
Strain Order & Shipping Details
Following ARLG approval of the request, the the ARLG Laboratory Center staff will email the final strain list to the contact person of the providing laboratory(ies). The ARLG Laboratory Center staff will also coordinate the shipment(s).
Yes, but requesting laboratory investigators will be responsible for shipping costs. Recipients will need to provide shipping information to the Laboratory Center staff.
Yes, the ARLG Laboratory Center staff will contact you to assist you with the process.
Upon request and approval by the ARLG Laboratory Center director, the ARLG Laboratory Center staff will ask the contributing laboratory to prepare an ARLG Virtual Biorepository culture (labeled with the assigned the ARLG Virtual Biorepository Identifier: ARLG‐ID) to be shipped to the requesting laboratory. Virtual biorepository strains are shipped on slants.
Investigators will be asked to include the strain ID assigned by the ARLG (e.g., ARLG‐1001) in any publication or presentation involving an ARLG strain.
Strain Submission to the ARLG Virtual Biorepository
- Strains must be published in peer‐reviewed journals and their inclusion in the Virtual Biorepository approved by the ARLG Laboratory Center director.
- Providing laboratories need to provide basic information about the strains to the ARLG Laboratory Center.
Yes, there is a process in place for the review and approval of all strains accepted into the Virtual Biorepository. Please e‐mail your request to email@example.com for more information. The strains will be incorporated in the Virtual Biorepository Catalogue only after approval by the ARLG Laboratory Center director and the ARLG subaward execution.
Once the strain culture is prepared for shipment and identified with anARLG‐ID, ARLG will provide oversight on the use of the strain.
Yes, to withdraw strains, please contact the ARLG Laboratory Center staff at Laboratory.Center@arlg.org