Clinical research studies cannot be performed without study participants who volunteer to be involved. The ARLG appreciates the time and commitment of these participants who play a significant role in advancing medical science. The ARLG is committed to providing lay summaries of results, which describe what researchers learned from the study in a language and format that is understandable and easy to read. In addition to the results, the summary includes information about why the research is needed, the purpose of the research, when the study was conducted, who was involved, what happened during the study, and how patients and researchers can use the results.
Rapid Diagnostics in Categorizing Acute Lung Infections (RADICAL) Study
Antibiotics are drugs that treat infections caused by bacteria, but they do not work on viruses, such as colds and the flu. Taking antibiotics when you do not need them can be harmful to you. It can also create drug-resistant bacteria, which is a serious public health issue that can lead to antibiotics that do not work and increased health care costs.
Doctors could better know when to prescribe an antibiotic if they had an easy and quick way to diagnose whether it was a virus or bacteria that caused a patient’s infection. Rather than trying to test for the presence of a virus or bacteria, the RADICAL study focuses on how patients respond to the infection.
Phase I Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Two Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Participants (PROOF)
Fosfomycin is approved for the treatment of urinary tract infections and cystitis, which is inflammation of the bladder.
The most recommended adult dose is three grams taken orally (by mouth) every other day, for a total of three doses. However, there are many different dosing regimens prescribed today that have not been studied or approved. In addition, based on activity observed in the lab, doctors are interested in prescribing this drug for its ability to treat infections caused by antibiotic-resistant bacteria (bacteria that are not controlled or killed by antibiotics). However, the drug has not been approved for this indication.
This study gathered information to help doctors identify alternative dosing regimens.