Consortium on Resistance against Carbapenems in Klebsiella Pneumoniae and other Enterobacteriaceae

An observational study that utilizes an existing CRKP consortium consisting of 20 hospitals that are part of 9 different health care systems. The primary objectives were:

1) To determine whether CRKP strain type is associated with outcomes in CRKP infections

2) To evaluate the constellation of clinical and microbiologic factors associated colistin and tigecycline non-suspectibility

3) To explore variation in treatment and outcomes of CRKP infections in various anatomical sites.

Collection of Rectal and Oropharyngeal Swabs from Healthy Volunteers

Collection of rectal and oropharyngeal swabs from healthy controls for the development of an assay

Platform Trial for the Evaluation of Antimicrobials for the Treatment of Multiple Resistant Bacterial Pathogens in Bacteremia

An innovative initiative to design and simulate a clinical platform trial that is customized to efficiently evaluate multiple experimental antimicrobial therapies for the treatment of multiple categories of infections (HAP/VAP, UTI and IA) due to MDR bacterial pathogens. The team consists of statisticians and clinicians from Berry Consultants, ARLG, GSK, Roche, AstraZeneca, The Medicines Company, JHU, BARDA, Sanofi, and the FDA.

http://www.berryconsultants.com/antibiotic-platform-design/