Stewardship

RESISTOME

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Duke RESISTOME (RESistance In Stem cell Transplant microbiome)

TITLE

The acquisition and persistence of antibiotic resistance genes in a high-risk pediatric population

DESCRIPTION
Aim 1: To determine the cumulative prevalence of antibiotic resistance genes in high-risk patients with frequent and prolonged contact with the healthcare system. We will evaluate clinical factors that predict acquisition of resistance genes and identify specific commensal bacteria and microbial community types that reduce the risk of acquisition of antibiotic resistance genes.
Aim 2: To evaluate the duration of retention of bacterial antibiotic resistance genes in a high-risk patient population. We will examine the persistence of antibiotic resistance genes in the gut microbiota of pediatric HSCT recipients after removal of the following selective pressures: 1) antibacterial therapy, 2) lack of enteral feeding, and 3) hospitalization.

ACUMIN

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TITLE
A Phase IV Open-Label Pharmacokinetic Study of Minocycline for Injection Following a Single Infusion in Critically-Ill Adults

Description
Characterize minocycline PK at the population level in critically-ill adults, with illness known or suspected to be caused by infection with Gram-negative bacteria. To assess patient-level and clinical covariates associated with minocycline pharmacokinetic properties in the same patient population.

BCID

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Film Array Blood Culture ID Panel
TITLE

Clinical and economic impact of rapid identification and susceptibility testing of pathogens growing in blood culture bottles. (Note: seed grant is to support economic analysis portion of the study)

DESCRIPTION
A prospective, randomized controlled trial with the primary objective being to determine if the BCID test either alone, or in combination with antimicrobial stewardship, will impact the antimicrobial utilization, clinical outcomes, and healthcare costs of patients with bloodstream infections