ARLG Grand Rounds: Evolving Clinical Resistance and Treatment Strategies for Novel β-lactam Agents against Pseudomonas aeruginosa June 2, 2023
Ryan K. Shields, PharmD, MS
Associate Professor of Medicine
Co-Director, Center for Innovative Antimicrobial Therapy
Co-Director, Antibiotic Management Program
University of Pittsburgh
The October 2023 newsletter features Dr. Michael Woodworth, MD, MSc, recipient of the Emory University Silver Pear Mentoring Award, as well as Tori Kinamon’s spotlight in the BBC StoryWorks film “Race Against Resistance.” Dive into the DOTS study’s enrollment achievement, ARLG’s partnership with Biomeme on the RADICAL 501k study, and the SHREC study’s summary of results.
In the July 2023 newsletter, you will find news about Melinda Pettigrew who was named Dean of the UMN School of Public Health, a feature in Duke’s Magnify Magazine on Tori Kinamon, and new IDSA guidance on the treatment of antimicrobial-resistant Gram-negative infections. You can read our mentee spotlight on Helen Zhang, find information on how to access past Grand Rounds events, and review the POP Study lay summary.
The University of Minnesota (UMN) has appointed Melinda Pettigrew as its new Dean of the School of Public Health. As a part of this new role, she will serve as the chief executive and chief academic officer.
Dr. Pettigrew is the Chair of the ARLG Diversity Working Group and a member of the Laboratory Center Consortium Team. Previously, she served as the interim Dean of the Yale School of Public Health (YSPH) where she is currently the Anna M. R. Lauder Professor of Epidemiology (Microbial Diseases) and the deputy dean of YSPH. Her research explores the effect of microbiome disruptions on antibacterial resistance and the risk for hospital-acquired infections.
The new appointment is the result of a highly competitive national candidate search and will begin in December 2023. Dr. Pettigrew’s leadership will help to advance the UMN School of Public Health’s goals to advance population health and health equity.
A June Magnify Magazine article titled “A Fighting Chance Against Infection” featured a profile on Tori Kinamon, ARLG Innovations Working Group member and MD Candidate at the Duke University School of Medicine.
In the article, Kinamon, a former gymnast who acquired a severe Methicillin-resistant Staphylococcus aureus (MRSA) infection during her freshman year of college at Brown University, detailed how that traumatic experience changed her perspective and inspired her to pursue a career in medicine.
As a medical student at Duke, Kinamon reached out to ARLG co-principal investigator, renowned researcher in S. aureus, and Florence McAlister Distinguished Professor of Medicine Dr. Vance Fowler, expressing her interest in infectious diseases research.
Kinamon has since authored multiple publications for scientific journals, participated in an ARLG panel discussion and an infectious disease conference in Dublin, Ireland, and was recently selected for an FDA Antibacterial Drug Resistance (DOOR) Fellowship – a competitive opportunity offered through the Oak Ridge Institute for Science and Education (ORISE). The fellowship evaluates ordinal endpoints using ARLG’s Desirability of Outcome Ranking (DOOR) approach for anti-infective clinical trials. DOOR is an innovative approach used in clinical trials to evaluate the global benefits and risks of an intervention.
Kinamon’s personal experience with a drug-resistant infection motivates her commitment to a patient-centered approach to care and the development of innovative treatments and preventive measures, including an infection prevention protocol for athletes, aiming to reduce the risk of infections like MRSA in athletic settings.
Kinamon emphasizes the importance of antibacterial research and development in the face of increasing rates of antibacterial resistance. She credits her fortunate access to an effective treatment for the positive outcome of her infection and expresses a passionate desire to provide the same opportunities for patients in the future.
“I don’t want to look a patient in the eye, or their family in the eye, and tell them they have an infection that we can’t treat. I want patients to have the outcome I was lucky enough to have,” Kinamon said.
Read the May 2023 newsletter and learn about a recent JAMA article on renewed interest in phage therapy featuring ARLG members and research. The ARLG spotlight this month is on Ahmed Babiker, recipient of the Early Faculty Seedling Award, who is studying how microbiome-based approaches lead to multidrug-resistant organism (MDRO) decolonization. Get updates on events, publications, study milestones, and more.
ARLG Grand Rounds: Straining For the Best Outcomes: Top Controversies in C. difficile Management March 3, 2023
Michael Woodworth, MD, MSc.
Assistant Professor, Division of Infectious Diseases
Emory University
Sarah Doernberg, MD, MAS
Associate Professor in the Division of Infectious Diseases
Medical Director, Adult Antimicrobial Stewardship
UCSF Medical Center
ARLG Grand Rounds:Dissecting The Epidemics of Multidrug-Resistant Organisms: A Focus on Carbapenem-Resistant Klebsiella pneumoniae February 4, 2022
Cesar A. Arias, MD, MSc, PhD
Professor of Medicine,
Co-director, Center for Infectious Diseases Research
Houston Methodist Hospital
Weill Cornell Medical College